# STOCKHOLM 1.0
#=GF ID   Cyclin_N
#=GF AC   PF00134.25
#=GF DE   Cyclin, N-terminal domain
#=GF PI   cyclin; 
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Sonnhammer ELL;0000-0002-9015-5588
#=GF AU   Griffiths-Jones SR;0000-0001-6043-807X
#=GF SE   Prosite
#=GF GA   20.50 20.50;
#=GF TC   20.50 20.50;
#=GF NC   20.40 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Cyclin
#=GF CL   CL0065
#=GF RC   The cyclins include an internal duplication, which is related to
#=GF RC   that found in TFIIB and the RB protein.
#=GF RN   [1]
#=GF RM   8152925
#=GF RT   Evidence for a protein domain superfamily shared by the cyclins,
#=GF RT   TFIIB and RB/p107. 
#=GF RA   Gibson TJ, Thompson JD, Blocker A, Kouzarides T; 
#=GF RL   Nucleic Acids Res 1994;22:946-952.
#=GF RN   [2]
#=GF RM   8591034
#=GF RT   The crystal structure of cyclin A 
#=GF RA   Brown NR, Noble MEM, Endicott JA, Garman EF, Wakatsuki S,
#=GF RA   Mitchell E, Rasmussen B, Hunt T, Johnson LN; 
#=GF RL   Structure. 1995;3:1235-1247.
#=GF RC   Complex of cyclin and cyclin dependent kinase.
#=GF RN   [3]
#=GF RM   8756328
#=GF RT   Structural basis of cyclin-dependant kinase activation by
#=GF RT   phosphorylation. 
#=GF RA   Russo AA, Jeffrey PD, Pavletich NP; 
#=GF RL   Nat Struct Biol. 1996;3:696-700.
#=GF RN   [4]
#=GF RM   2001396
#=GF RT   Isolation and characterization of a human cDNA encoding
#=GF RT   uracil-DNA glycosylase. 
#=GF RA   Muller SJ, Caradonna S; 
#=GF RL   Biochim Biophys Acta 1991;1088:197-207.
#=GF DR   INTERPRO; IPR006671;
#=GF DR   PROSITE; PDOC00264;
#=GF DR   SCOP; 1vin; fa;
#=GF DR   HOMSTRAD; cyclin;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674
#=GF CC   is a Uracil-DNA glycosylase that is related to other cyclins
#=GF CC   [4]. Cyclins contain two domains of similar all-alpha fold, of
#=GF CC   which this family corresponds with the N-terminal domain.
#=GF SQ   95
#=GS CCNB3_CAEEL/115-241       AC Q10654.3
#=GS T1FNQ9_HELRO/256-381      AC T1FNQ9.1
#=GS CCNB3_DROME/308-433       AC Q9I7I0.1
#=GS CCNB3_CHICK/149-274       AC P39963.1
#=GS CCB31_ARATH/146-272       AC Q9SA32.2
#=GS CCNB1_SOYBN/197-322       AC P25011.1
#=GS CCB11_ARATH/168-293       AC P30183.2
#=GS CCB12_ARATH/185-310       AC Q39067.2
#=GS M1A5P4_SOLTU/185-310      AC M1A5P4.1
#=GS I1M770_SOYBN/186-311      AC I1M770.1
#=GS CCB14_ARATH/133-258       AC O48790.1
#=GS B8A2G9_MAIZE/228-354      AC B8A2G9.1
#=GS B4FZZ7_MAIZE/193-318      AC B4FZZ7.1
#=GS K7V0X7_MAIZE/191-316      AC K7V0X7.1
#=GS CCB21_ORYSJ/157-283       AC Q7XSJ6.2
#=GS CCB21_ARATH/174-300       AC Q39068.2
#=GS Q9XGI1_SOLLC/180-306      AC Q9XGI1.1
#=GS C4J9B6_MAIZE/173-299      AC C4J9B6.1
#=GS CCB24_ARATH/180-307       AC Q9SFW6.2
#=GS CCNB_DICDI/188-314        AC P42524.1
#=GS O45926_CAEEL/34-159       AC O45926.2
#=GS CCNB1_CAEEL/81-206        AC Q10653.1
#=GS P92162_BOMMO/260-387      AC P92162.1
#=GS CCNB_DROME/260-387        AC P20439.2
#=GS F6QF79_XENTR/139-264      AC F6QF79.3
#=GS CCNB1_MOUSE/170-295       AC P24860.3
#=GS Q28HA1_XENTR/132-257      AC Q28HA1.1
#=GS CCNB2_HUMAN/137-262       AC O95067.1
#=GS CCNB2_CHICK/141-266       AC P29332.1
#=GS A0BXX7_PARTE/85-212       AC A0BXX7.1
#=GS Q6BFS2_PARTE/82-210       AC Q6BFS2.1
#=GS CG21_CANAL/208-334        AC Q5ALY0.1
#=GS CGS5_YEAST/165-294        AC P30283.1
#=GS CGS6_YEAST/123-252        AC P32943.2
#=GS CG21_YEAST/212-337        AC P24868.1
#=GS CG22_YEAST/232-357        AC P24869.1
#=GS CG24_CANAL/234-360        AC Q5A0A9.1
#=GS CG23_YEAST/171-297        AC P24870.3
#=GS CG24_YEAST/210-336        AC P24871.2
#=GS CG22_SCHPO/139-265        AC P36630.2
#=GS M7PCR8_PNEMU/176-302      AC M7PCR8.1
#=GS CG21_EMENI/211-337        AC P30284.1
#=GS CG23_SCHPO/206-332        AC P10815.1
#=GS CG21_SCHPO/166-292        AC P24865.2
#=GS REM1_SCHPO/145-271        AC O14332.1
#=GS CCNF_MOUSE/282-406        AC P51944.2
#=GS I1K835_SOYBN/85-214       AC I1K835.1
#=GS J3KY10_ORYBR/200-327      AC J3KY10.1
#=GS M4E4A3_BRARP/154-281      AC M4E4A3.1
#=GS CCA22_ARATH/175-302       AC Q147G5.1
#=GS Q39878_SOYBN/207-334      AC Q39878.1
#=GS T1EGC7_HELRO/166-291      AC T1EGC7.1
#=GS CCNA1_CAEEL/215-341       AC P34638.2
#=GS CCNA_DROME/206-332        AC P14785.3
#=GS W4XJF2_STRPU/207-333      AC W4XJF2.1
#=GS CCNA2_MOUSE/171-297       AC P51943.2
#=GS CCNA2_MOUSE/171-297       DR PDB; 4I3Z D; 181-307;
#=GS CCNA2_MOUSE/171-297       DR PDB; 4II5 D; 181-307;
#=GS CCNA2_MOUSE/171-297       DR PDB; 4I3Z B; 181-307;
#=GS CCNA2_MOUSE/171-297       DR PDB; 4II5 B; 181-307;
#=GS CCNA2_MOUSE/171-297       DR PDB; 3QHW B; 181-307;
#=GS CCNA2_MOUSE/171-297       DR PDB; 3QHW D; 181-307;
#=GS CCNA2_MOUSE/171-297       DR PDB; 3QHR D; 181-307;
#=GS CCNA2_MOUSE/171-297       DR PDB; 3QHR B; 181-307;
#=GS E9QJ66_DANRE/140-266      AC E9QJ66.1
#=GS CCNA1_HUMAN/214-340       AC P78396.1
#=GS CG12_YEAST/43-195         AC P20438.2
#=GS PUC1_SCHPO/99-227         AC P25009.1
#=GS CG13_CANAL/44-172         AC Q5A1N6.1
#=GS CG11_CANAL/44-172         AC Q59YH3.2
#=GS CGH2_SHV21/22-148         AC Q01043.1
#=GS CGH2_SHV21/22-148         DR PDB; 1JOW A; 22-148;
#=GS CGH2_SHV21/22-148         DR PDB; 1BU2 A; 22-148;
#=GS CGH2_SHV21/22-148         DR PDB; 2EUF A; 22-148;
#=GS CGH2_SHV21/22-148         DR PDB; 4TTH A; 22-148;
#=GS CGH2_SHV21/22-148         DR PDB; 1XO2 A; 22-148;
#=GS CGH2_SHV21/22-148         DR PDB; 2F2C A; 22-148;
#=GS VCYCL_HHV8P/21-147        AC Q77Q36.1
#=GS CCND_CAEEL/72-201         AC Q9U2M5.1
#=GS Q7KUZ5_DROME/153-280      AC Q7KUZ5.1
#=GS CCND1_RAT/26-153          AC P39948.1
#=GS CCND2_MOUSE/24-151        AC P30280.1
#=GS CCND3_HUMAN/26-153        AC P30281.2
#=GS CCND3_HUMAN/26-153        DR PDB; 3G33 D; 26-153;
#=GS CCND3_HUMAN/26-153        DR PDB; 3G33 B; 26-153;
#=GS Q9VZP3_DROME/42-165       AC Q9VZP3.1
#=GS SSN8_YEAST/45-176         AC P47821.1
#=GS CCC11_ORYSJ/4-144         AC P93411.1
#=GS CCNT_DROME/42-176         AC O96433.2
#=GS CCT12_ARATH/28-169        AC Q56YF8.2
#=GS Q9VE72_DROME/6-144        AC Q9VE72.1
#=GS PCL1_YEAST/19-152         AC P24867.1
#=GS PCL2_YEAST/18-146         AC P25693.2
#=GS PCL9_YEAST/19-146         AC Q12477.1
#=GS CCU41_ARATH/23-148        AC O80513.1
#=GS Q9VKF0_DROME/205-327      AC Q9VKF0.1
#=GS CCD11_ARATH/50-182        AC P42751.3
#=GS CCD21_ARATH/65-197        AC P42752.3
#=GS CCD41_ARATH/45-178        AC Q8LGA1.2
#=GS Q9SMD4_SOLLC/51-182       AC Q9SMD4.1
#=GS Q9S7H9_SOLLC/61-190       AC Q9S7H9.1
#=GS CCD33_ARATH/59-186        AC Q9SN11.1
#=GS CCD61_ARATH/26-154        AC Q9ZR04.1
#=GS CCNE_DROME/330-459        AC P54733.2
#=GS CCNE2_MOUSE/112-239       AC Q9Z238.1
#=GS CCNE1_CHICK/112-239       AC P49707.1
#=GS CCNE1_MOUSE/113-240       AC Q61457.2
#=GS A0A0R4IZF8_DANRE/117-244  AC A0A0R4IZF8.1
#=GS F6QUN0_XENTR/114-241      AC F6QUN0.2
#=GS W4XEA0_STRPU/126-253      AC W4XEA0.1
#=GS CCNE_CAEEL/232-360        AC O01501.2
CCNB3_CAEEL/115-241                  GIFDYYRHREV...HFRVRKYL..HKHPE...VDV.KTRAILIDW...MVEIQETFELNHETLYNAVKLTDMYLCKTK.NVDKN......TIQKLACVAIFIAAKY.......................DERS..PPLVDDLIYLS..............GD..RFSRDELLAMERELFATVGYDLG
T1FNQ9_HELRO/256-381                 DIFDYYRDREV...KFRIPDYM..FQQTD...LTP.SMRAILVDW...LVEVQQSFELNHETLYMAVKLIDIFSS.KV.TIKRN......KLQLIGAVALNLACKF.......................EERC..PPMLDDFVYVC..............DD..AYPRQEFLKMEELVFQAVGFDIG
CCNB3_DROME/308-433                  DIFNYLKVREA...EFPIADYM..PRQIH...LTT.WMRTLLVDW...MVEVQETFELNHETLYLAVKIVDLYLC.RE.VINKE......KLQLLGAAAFFIACKY.......................DERQ..PPLIEDFLYIC..............DG..AYNHDELVRMERETLRVIKYDLG
CCNB3_CHICK/149-274                  EIFDYMREREE...KFLLPDYM..EKQSD...ISR.DMRAILVDW...MVEVQENFELNHETLYLAVKLVDHYLV.EV.VSMRD......KLQLIGSTAVLIASKF.......................EERC..PPCVDDFLYIC..............DD..AYKREELIAMETSILRTLNFDIN
CCB31_ARATH/146-272                  DIYQFYWTAEA..LNPALGHYL..SAHAE...VSP.VTRGILINW...LIEVHFKFDLMHETLYLTMDLLDRYLS.QV.PIHKN......EMQLIGLTALLLASKY.......................EDYW..HPRIKDLISIS..............AE..SYTREQILGMERSMLKQLKFRLN
CCNB1_SOYBN/197-322                  DIYKFYKLVEN..ESRP.HDYI..GSQPE...INE.RMRAILVDW...LIDVHTKFELSLETLYLTINIIDRFLA.VK.TVPRR......ELQLVGISAMLMASKY.......................EEIW..PPEVNDFVCLS..............DR..AYTHEHILTMEKTILNKLEWTLT
CCB11_ARATH/168-293                  DIYSFYKSVES..EWRP.RDYM..ASQPD...INE.KMRLILVEW...LIDVHVRFELNPETFYLTVNILDRFLS.VK.PVPRK......ELQLVGLSALLMSAKY.......................EEIW..PPQVEDLVDIA..............DH..AYSHKQILVMEKTILSTLEWYLT
CCB12_ARATH/185-310                  DMYSFYKEVEK..ESQP.KMYM..HIQTE...MNE.KMRAILIDW...LLEVHIKFELNLETLYLTVNIIDRFLS.VK.AVPKR......ELQLVGISALLIASKY.......................EEIW..PPQVNDLVYVT..............DN..AYSSRQILVMEKAILGNLEWYLT
M1A5P4_SOLTU/185-310                 DIYKFYKLTED..ENRP.CDYM..DSQPE...IND.RVRAILVDW...LIEAHKRFELRPESLYLTVNIMDRFLS.EE.TVPRR......ELQLLCISSMLIACKY.......................EEIW..APEVNDFLTIT..............DN..AYVRDQILLMEKVILGKLEWYLT
I1M770_SOYBN/186-311                 DIYKFYKETEE..DGCV.HDYM..GSQPD...INA.KMRSILVDW...LIEVHRKFELMPETLYLTLNIVDRFLS.VK.AVPRR......ELQLVGISSMLIASKY.......................EEIW..APEVNDFVCIS..............DN..AYVSEQVLMMEKTILRKLEWYLT
CCB14_ARATH/133-258                  DIFKFYRTVEE..EGGI.KDYI..GSQPE...INE.KMRSILIDW...LVDVHRKFELMPETLYLTINLVDRFLS.LT.MVHRR......ELQLLGLGAMLIACKY.......................EEIW..APEVNDFVCIS..............DN..AYNRKQVLAMEKSILGQVEWYIT
B8A2G9_MAIZE/228-354                 DIYRFYKSTEG..TCLPLSSYM..SSQAE...ISE.RMRAILIDW...IIEVQYRLTLMPETLYLTVYIIDQYLS.ME.SVPRK......ELQLVGISAMLIASKY.......................EEIW..APLVKDLMCLC..............DN..AFTRDQILTKEKAILDMLHWNLT
B4FZZ7_MAIZE/193-318                 DIYTFYKIAQH..DRRP.CDYI..DTQVE...INP.KMRAILAGW...IIEVHHKFELMPETLYLTMYIIDQYLS.LQ.PVLRR......ELQLVGVSAMLIACKY.......................EEIW..APEVNDFILIS..............DS..AYSREQILSMEKGILNSLEWNLT
K7V0X7_MAIZE/191-316                 DIYTFYKTAQH..ESRP.IDYM..GNQPE...LSP.RMRSILADW...LIESHRRFQLMPETLYLTIYIVDRYLS.LQ.PTPRR......ELQLVGVAALLIACKY.......................EEIW..APEVNDLIHIA..............DG..AFNRSQILAAEKAILNSMEWNLT
CCB21_ORYSJ/157-283                  ELYKFYRENEE..MSCVQPDYM..SSQGD...INE.KMRAILIDW...LIEVHHKFELMDETLFLTVNIVDRFLE.KQ.VVPRK......KLQLVGVTAMLLACKY.......................EEVA..VPVVEDLVLIS..............DR..AYTKGQILEMEKLILNTLQFNMS
CCB21_ARATH/174-300                  DLYAFYRTMER..FSCVPVDYM..MQQID...LNE.KMRAILIDW...LIEVHDKFDLINETLFLTVNLIDRFLS.KQ.NVMRK......KLQLVGLVALLLACKY.......................EEVS..VPVVEDLVLIS..............DK..AYTRNDVLEMEKTMLSTLQFNIS
Q9XGI1_SOLLC/180-306                 DLFANYRTMEV..NSCASPYYM..AQQAD...INE.RMRSILIDW...LIEVHHKFELREETLFLTVNLIDRFLE.KQ.GIVRK......KLQLVGLVAMLLACKY.......................EEVC..APLVEDLVLIS..............DK..AYTRKEVLEMESMMLNTLQFNMS
C4J9B6_MAIZE/173-299                 EIYRFYRKTEG..ASCVPTNYM..SSQTD...INE.KMRGILIDW...LIEVHYKLELLEETLFLTVNIIDRFLA.RE.NVVRK......KLQLAGVTAMLLACKY.......................EEVS..VPVVEDLILIC..............DR..AYTRADILEMERRIVNTLNFNMS
CCB24_ARATH/180-307                  DIYCFYKKNEC..RSCVPPNYM..ENQHD...INE.RMRGILFDW...LIEVHYKFELMEETLYLTINLIDRFLAVHQ.HIARK......KLQLVGVTAMLLACKY.......................EEVS..VPVVDDLILIS..............DK..AYTRTEILDMEKLMANTLQFNFC
CCNB_DICDI/188-314                   EIFAYYREKEQ..IDKIDKDYI..KNQYH...INE.RMRAILVDW...MMAVHVRFKLLSETFFLSVNIVDRYLA.KV.MIPVT......KLQLVGITAILLACKY.......................EEIY..SPQIKDFVHTS..............DD..ACTHAEVIDMERQILSTLQFHMS
O45926_CAEEL/34-159                  DIYNYLVHHEK..KYVLDDSFI......NGGNVNS.KMRRILVDW...LIQVHLRFHLTPETLHLTIFVLDRIIV.KN.IVSKA......EFQLLGVAALFVASKF.......................EDIY..LPDILEYEMIT..............DN..TFSKKQIMAMEQTILNALNFDLS
CCNB1_CAEEL/81-206                   DIYKYLVHHEK..KYLLEECFM......EGGEPTP.KMRRILVDW...LVQVHVRFHLTPETLHLTVFILDRMLQ.KK.VTSKA......DLQLLGISAMFVASKF.......................EEVY..LPDIHDYEFIT..............EN..TYSKKQILAMEQTILNSLNFDLS
P92162_BOMMO/260-387                 DIYKYLTELEE..KYSIEPDHL..KKQTV...ITG.KMRATLIDW...LVEVQRQFSLVLETFHLTVGIIDRYLQVVP.NVQRN......QLQLVGVTAMFIASKY.......................EEIY..APDVGDFVYVT..............DN..AYTKSDVFRCERDIMCKLGFCLA
CCNB_DROME/260-387                   DIYDYLYQVEL..EQPIHKDHL..AGQKE...VSH.KMRAVLIDW...INEVHLQFHLAAETFQLAVAIIDRYLQVVK.DTKRT......YLQLVGVTALFIATKY.......................EELF..PPAIGDFVFIT..............DD..TYTARQIRQMELQIFKAIDCNLS
F6QF79_XENTR/139-264                 DIYCYLRSLEN..AQAVRQNYL..HG.QE...VTG.NMRAILIDW...LVQVQMKFRLLQETMFMTVGIIDRFLQ.DH.PVPKN......QLQLVGVTAMFLAAKY.......................EEMY..PPEIGDFTFVT..............DH..TYTKAQIRDMEMKVLRVLKFAIG
CCNB1_MOUSE/170-295                  DIYAYLRQLEE..EQSVRPKYL..QG.RE...VTG.NMRAILIDW...LIQVQMKFRLLQETMYMTVSIIDRFMQ.NS.CVPKK......MLQLVGVTAMFIASKY.......................EEMY..PPEIGDFAFVT..............NN..TYTKHQIRQMEMKILRVLNFSLG
Q28HA1_XENTR/132-257                 DIYNYLKQLEV..QQSVRPCYL..EG.KE...INE.RMRAILVDW...IVQVHSRFQLLQETLYMGIAIMDRFLQ.VQ.PVSRS......KLQLVGVTSLLVASKY.......................EEMY..TPEVADFVYIT..............DN..AYTASQIREMEMIILRVLNFDLG
CCNB2_HUMAN/137-262                  DIYQYLRQLEV..LQSINPHFL..DG.RD...ING.RMRAILVDW...LVQVHSKFRLLQETLYMCVGIMDRFLQ.VQ.PVSRK......KLQLVGITALLLASKY.......................EEMF..SPNIEDFVYIT..............DN..AYTSSQIREMETLILKELKFELG
CCNB2_CHICK/141-266                  DIYLYLRQLEL..QQSVRPHYL..DG.KT...ING.RMRAILVDW...LVQVHSRFQLLQETLYMCVAVMDRFLQ.SH.PVPRK......RLQLVGVTALLLASKY.......................EEMY..SPDIADFVYIT..............DN..AYNSAEVREMEITILKELNFDLG
A0BXX7_PARTE/85-212                  EILQHLLIEEN..KYTI.NQYMTPEQQPD...INI.KMRAILVDW...LIDVHAKFKLKDETLYITISLIDRYLA.LA.QVTRM......RLQLVGVAALFIACKY.......................EEIY..PPALKDFVYIT..............DN..AYVKSDVLEMEGLMLQALNFNIC
Q6BFS2_PARTE/82-210                  EIYTYLLTQEE..KYLVSNNYMNEQQQPD...LNA.RMRAILLDW...LIDVHLKFKLRDETLYVTTYLIDRFLN.FK.TTTRQ......QLQLVGVASLFIACKY.......................EEIY..PPDLKDFVYIT..............DN..AYTKQDVLEMEGQILQTLDFSIT
CG21_CANAL/208-334                   EIFSYYYELET..RMLPDPQYL..FKQTL...LKP.RMRSILVDW...LVEMHLKFKLLPESLFLAVNVMDRFMS.VE.VVQID......KLQLLATAALFTAAKY.......................EEVF..SPSVKNYAYFT..............DG..SYTPEEVVQAEKYMLTILNFDLN
CGS5_YEAST/165-294                   EIFAFLYRREL..ETLPSHNYL..LDKTSKYYLRP.SMRTILVDW...LVEVHEKFQCYPETLFLSINLMDRFLA.KN.KVTMN......KLQLLAVTSLFIAAKF.......................EEVN..LPKLAEYAYIT..............DG..AASKNDIKNAEMFMLTSLEFNIG
CGS6_YEAST/123-252                   SIFSHLYEKEI..QMLPTHNYL..MDTQSPYHLKS.SMRALLIDW...LVEVHEKFHCLPETLFLAINLLDRFLS.QN.VVKLN......KLQLLCITCLFIACKF.......................EEVK..LPKITNFAYVT..............DG..AATVEGIRKAELFVLSSLGYNIS
CG21_YEAST/212-337                   DIFDYLHHLEI..ITLPNKANL..YKHKN...IK..QNRDILVNW...IIKIHNKFGLLPETLYLAINIMDRFLC.EE.VVQLN......RLQLVGTSCLFIASKY.......................EEIY..SPSIKHFAYET..............DG..ACSVEDIKEGERFILEKLDFQIS
CG22_YEAST/232-357                   DIFEYLHQLEV..ITLPKKEDL..YQHRN...IH..QNRDILVNW...LVKIHNKFGLLPETLYLAINIMDRFLG.KE.LVQLD......KLQLVGTSCLFIASKY.......................EEVY..SPSIKHFASET..............DG..ACTEDEIKEGEKFILKTLKFNLN
CG24_CANAL/234-360                   EIFNYLHELEN..KFTPDPNYM..DFQDD...LKW.EMRAVLIDW...VVQVHARFNLFSETLYLTVNYIDRFLS.KR.RVSLS......RFQLVGAVALFIAAKY.......................EEIN..CPTVQEIAYMA..............DN..AYSIDEFLKAERFMIDVLEFDLG
CG23_YEAST/171-297                   EIFEYMRKLED..LYKPNPYYM..DKQPE...LRW.SFRSTLIDW...IVQVHEKFQLLPETLYLCINIIDRYLC.KE.VVPVN......KFQLVGAASLFIAAKY.......................EEIN..CPTIKDFVYMS..............EN..CYSRNDLLDAERTILNGLEFELG
CG24_YEAST/210-336                   DIFYYLRELEV..KYRPNPYYM..QNQVE...LTW.PFRRTMIDW...LVQLHFRFQLLPETLYLTINIVDRFLS.KK.TVTLN......RFQLVGVSALFIAAKF.......................EEIN..CPTLDDLVYML..............EN..TYTRDDIIRAEQYMIDTLEFEIG
CG22_SCHPO/139-265                   EIFEYIRKLDL..KCLPNPKYM..DQQKE...LTW.KMREILNEW...LVEIHSNFCLMPETLYLAVNIIDRFLS.RR.SCSLS......KFQLTGITALLIASKY.......................EEVM..CPSIQNFVYMT..............DG..AFTVEDVCVAERYMLNVLNFDLS
M7PCR8_PNEMU/176-302                 EIMSYMRELEV..LTLPLPDYM..DRQKE...LQW.KMRGILVDW...LIEVHAKFRLLPETLFLSVNIIDRFLS.LR.VCSLP......KLQLVGITALFIAAKY.......................EEVM..CPSIQNFMYMA..............DG..GYTNEEILKAEQYVLQVLGYDMS
CG21_EMENI/211-337                   EIFDYLRELEM..ETLPNPDYI..DHQPD...LEW.KMRGILVDW...LIEVHTRFRLLPETLFLAVNIIDRFLS.AE.VVALD......RLQLVGVAAMFIASKY.......................EEVL..SPHVANFSHVA..............DE..TFSDKEILDAERHILATLEYNMS
CG23_SCHPO/206-332                   DIFEYLNELEI..ETMPSPTYM..DRQKE...LAW.KMRGILTDW...LIEVHSRFRLLPETLFLAVNIIDRFLS.LR.VCSLN......KLQLVGIAALFIASKY.......................EEVM..CPSVQNFVYMA..............DG..GYDEEEILQAERYILRVLEFNLA
CG21_SCHPO/166-292                   EIFHYMQSLER..KLAPPPNYM..SVQQE...IDW.VTRHMLVDW...IVQVQIHFRLLPETLFLAVNLIDRFLS.IK.VVSLQ......KVQLVGLSALLIACKY.......................EEIH..PPSIYNFAHVV..............QG..IFTVDEIIRAERYMLMLLDFDIS
REM1_SCHPO/145-271                   EILSHMEKLEI..RFMPDYRHM..SAQPY...YVT.EMRASVINW...IVGVHTCINLLPESLFLSINVLDRFLS.LQ.NVPAS......KMKLCGATALFIACKY.......................EEIH..PPTVKDLEIVL..............EG..EWIGEDICGMEKYMLMVLQYQLG
CCNF_MOUSE/282-406                   SVCQLFQASQA....VNKQQIF..SVQKG...LSD.TMRYILIDW...LVEVATMKDFTSLCLHLTVECVDRYLR.RR.LVPRY......KLQLLGIACMVICTRFI.....................SKEIL....TIREAVWLT..............DN..TYKYEDLVRVMGEIISALEGKIR
I1K835_SOYBN/85-214                  DIHGYLREMEMQNKRRPMVDYI.EKVQKI...VTP.TMRAILVDW...LVEVAVEYKLLSDTLHLSVSYIDRFLS.VN.PVSKS......RLQLLGVSSMLIAAKY.......................EEMD..PPGVDEFCSIT..............DH..TYDKTEVVKMEADILKSLKFEMG
J3KY10_ORYBR/200-327                 DIYMHLREAET..RKRPSTDFM.ETIQKD...VNP.SMRAILIDW...LVEVAEEYRLVPDTLYLTVNYIDRYLS.GN.EINRQ......RLQLLGVACMLIAAKY.......................EEIC..APQVEEFCYIT..............DN..TYFRDEVLEMEASVLNYLKFEMT
M4E4A3_BRARP/154-281                 DIYNHLRAAEA..KKQPAVDYM.ATVQKD...VNS.TMRGILVDW...LVEVSEEYRLVPETLYLTVNYIDRYLS.GN.VISRQ......KLQLLGVACMMIAAKY.......................EEVC..APQVEEFCYIT..............DN..TYLKDEVLDMESAVLNYLKFEMS
CCA22_ARATH/175-302                  DIYDNIHVAEL..QQRPLANYM.ELVQRD...IDP.DMRKILIDW...LVEVSDDYKLVPDTLYLTVNLIDRFLS.NS.YIERQ......RLQLLGVSCMLIASKY.......................EELS..APGVEEFCFIT..............AN..TYTRPEVLSMEIQILNFVHFRLS
Q39878_SOYBN/207-334                 DIYSNIRVTEL..QRKPLTNYM.DKLQKD...INP.SMRGILVDW...LVEVSEEYKLVPDTLYLTVNLIDRYLS.TR.LIQKQ......KLQLLGVTCMLIASKY.......................EEMC..APRVEEFCFIT..............DN..TYTKEEVLKMEREVLNLVHFQLS
T1EGC7_HELRO/166-291                 DILTYGKEAEQ..RYMAKANYM..ERQSD...INH.SMRSILVDW...LVEVADEYKLKRETFFLAVNYIDRFLS.MM.SVIRC......RLQLLGAAAMFIAAKY.......................EEIY..PPDVAEFVYIT..............DD..TYTMKQVLQMEQAILKTLNF.LV
CCNA1_CAEEL/215-341                  DIIKYMLHRQT..KNRASHECF..DIQSQ...VNE.EMRTILIDW...FSDVVKEYNFQKETFHLAVSLVDRALS.MF.NIDKM......RFQLVGTTSMMIAVKY.......................EEIF..PPEIEDFALIT..............DN..TYRVPDILLMERFLLGKFDFVVA
CCNA_DROME/206-332                   DILEYFRESEK..KHRPKPLYM..RRQKD...ISH.NMRSILIDW...LVEVSEEYKLDTETLYLSVFYLDRFLS.QM.AVVRS......KLQLVGTAAMYIAAKY.......................EEIY..PPEVGEFVFLT..............DD..SYTKAQVLRMEQVILKILSFDLC
W4XJF2_STRPU/207-333                 EIYQYLKTAES..KHRPKHGYM..RKQPD...ITN.SMRCILVDW...LVEVSEEYRLHNETLYLAAAFIDRFLS.QM.SVLRA......KLQLVGTASMFVASKY.......................EEIY..PPDVKEFVYIT..............DD..TYSIKQVLRMEHLILKVLSFDLA
CCNA2_MOUSE/171-297                  DIHTYLREMEV..KCKPKVGYM..KRQPD...ITN.SMRAILVDW...LVEVGEEYKLQNETLHLAVNYIDRFLS.SM.SVLRG......KLQLVGTAAMLLASKF.......................EEIY..PPEVAEFVYIT..............DD..TYSKKQVLRMEHLVLKVLAFDLA
#=GR CCNA2_MOUSE/171-297       SS    HHHHHHHHHHH..HT---TTGG..GG-SS...--H.HHHHHHHHH...HHHHHHHTT--HHHHHHHHHHHHHHHC.C-.---CC......CHHHHHHHHHHHHHHH.......................H-SS..---HHHHHHHT..............TT..SS-HHHHHHHHHHHHHHHTT---
E9QJ66_DANRE/140-266                 DIHRYLRECEV..KYRPKPGYM..RKQPD...ITN.CMRVILVDW...LVEVGEEYKLCSETLYLAVNYLDRFLS.CM.SVLRG......KLQLVGTAAILLAAKY.......................EEVY..PPEVDEFVYIT..............DD..TYTKKQLLRMEQHLLRVLAFDMT
CCNA1_HUMAN/214-340                  EIYQYLREAEI..RHRPKAHYM..KKQPD...ITE.GMRTILVDW...LVEVGEEYKLRAETLYLAVNFLDRFLS.CM.SVLRG......KLQLVGTAAMLLASKY.......................EEIY..PPEVDEFVYIT..............DD..TYTKRQLLKMEHLLLKVLAFDLT
CG12_YEAST/43-195                    EISTNVIAQSC..KFKPNPKLI..DQQPE...MNPVETRSNIITF...LFELSVVTRVTNGIFFHSVRLYDRYCS.KR.IVLRD......QAKLVVATCLWLAAKTWGGCNHIINNVVIPTGGRFYGPNPRAR..IPRLSELVHYC..............GDGQVFDESMFLQMERHILDTLNWNIY
PUC1_SCHPO/99-227                    DIIHHLITREK..NFLLNVHLS..NQQPE...LRW.SMRPALVNF...IVEIHNGFDLSIDTLPLSISLMDSYVS.RR.VVYCK......HIQLVACVCLWIASKF.......................HETEDRVPLLQELKLAC..............KN..IYAEDLFIRMERHILDTLDWDIS
CG13_CANAL/44-172                    EMLHHLLSVEA..KTLPNLSLI..EQQPE...IKL.GMRPLLLDF...LMEVITILSLSRSTFPLTVNLIDRYCS.TR.IVKKQ......HYQLLGLTSLWISCKN.......................LDSKFKVPTLNDLRKIC..............VD..SYYKELFVEMEKHILKSLEWVVN
CG11_CANAL/44-172                    DIVNTLSQLES..LTLVNPAMI..DLQPE...IQW.FMRPFLLDF...LIELHSSFKLQPTTLFLCLNIIDRYCA.KR.IVFKR......HYQLVGCTALWIASKY.......................EDKKSRVPTLKELTIMC..............RN..AYDEEMFVQMEMHILSTLDWSIG
CGH2_SHV21/22-148                    RVLNNLKLREL...LLPKFTSL.WEIQTE...VTV.DNRTILLTW...MHLLCESFELDKSVFPLSVSILDRYLC.KK.QGTKK......TLQKIGAACVLIGSKI.......................RTVK..PMTVSKLTYLS..............CD..CFTNLELINQEKDILEALKWDTE
#=GR CGH2_SHV21/22-148         SS    HHHHHHHHHHT...TS---SST.TTT-SS...S-H.HHHHHHHHH...HHHHHHHTT--TTHHHHHHHHHHHHHH.HS.---TT......THHHHHHHHHHHHHHH.......................HSSS..---HHHHHHTT..............TT..SS-HHHHHHHHHHHHHHTTT---
VCYCL_HHV8P/21-147                   .IFYNILEIEP..RFLTSDSVFGTFQQS....LTS.HMRKLLGTW...MFSVCQEYNLEPNVVALALNLLDRLLL.IK.QVSKE......HFQKTGSACLLVASKL.......................RSLT..PISTSSLCYAA..............AD..SFSRQELIDQEKELLEKLAWRTE
CCND_CAEEL/72-201                    DMRAFYNCMEYEEALQPNYHYF.TGVQEN...ITP.FHREQAIDW...IYDVAKEENCDGDVFLLAVSLIDRFMS.VQ.NILKH......DIQMIAGVALFIASKL.......................KAPH..PMTASKIAYYS..............DN..SCPIDMILQWELLIVTTLQWETE
Q7KUZ5_DROME/153-280                 ..LENFLKVEEKHHKIPDTYF...SIQKD...ITP.PMRKIVAEW...MMEVCAEENCQEEVVLLALNYMDRFLS.SK.SVRKT......QLQILAAACLLLASKL.......................REPSCRALSVDLLVVYT..............DN..SIYKDDLIKWELYVLSRLGWDLS
CCND1_RAT/26-153                     RVLRAMLKTEE..TCAPSVSYF.KCVQRE...IVP.SMRKIVATW...MLEVCEEQKCEEEVFPLAMNYLDRFLS.LE.PLKKS......RLQLLGATCMFVASKM.......................KETI..PLTAEKLCIYT..............DN..SIRPEELLQMELLLVNKLKWNLA
CCND2_MOUSE/24-151                   RVLQNLLTIEE..RYLPQCSYF.KCVQKD...IQP.YMRRMVATW...MLEVCEEQKCEEEVFPLAMNYLDRFLA.GV.PTPKT......HLQLLGAVCMFLASKL.......................KETI..PLTAEKLCIYT..............DN..SVKPQELLEWELVVLGKLKWNLA
CCND3_HUMAN/26-153                   RVLQSLLRLEE..RYVPRASYF.QCVQRE...IKP.HMRKMLAYW...MLEVCEEQRCEEEVFPLAMNYLDRYLS.CV.PTRKA......QLQLLGAVCMLLASKL.......................RETT..PLTIEKLCIYT..............DH..AVSPRQLRDWEVLVLGKLKWDLA
#=GR CCND3_HUMAN/26-153        SS    HHHHHHHHHGG..GGS-SS--T.TTSTTT...--H.HHHHHHHHH...HHHHHHHTT--TTHHHHHHHHHHHHHH.H-.---GG......GHHHHHHHHHHHHHHH.......................H-SS..---TTHHHHHT..............TT..SS-HHHHHHHHHHHHHHTTT---
Q9VZP3_DROME/42-165                  DIFLTMREQEL.............SRRPLFYLSPQLNERRRMLQL...LKLATSAHKLSRCALHLAVYYMDRFVD.YY.KIRPD......KLLLVAITCLHIAAQI.......................ENTDAFIPRYSEMNRLV..............KN..AYTAFEYKAVERKILCFLNFELI
SSN8_YEAST/45-176                    DSKQNGIEQSITKNIPITHRDLHYDKDYN........LRIYCYFL...IMKLGRRLNIRQYALATAHIYLSRFLI.KA.SVREI......NLYMLVTTCVYLACKV.......................EEC...PQYIRTLVSEART..........LWPEFIPPDPTKVTEFEFYLLEELESYLI
CCC11_ORYSJ/4-144                    ....NFWTSSHCKQLLDQEDVDKVPQADSDRGITLEEFRLVKIHMSFHIWRLAQQVKVRQRVIATAVTYFRRVYT.RK.SMTEY......DPRLVAPTCLYLASKV.......................EES...TVQARLLVFYIKKM........CASDEKYRFEIKDILEMEMKLLEALDYYLV
CCNT_DROME/42-176                    DKIWYFSNDQL.ANSPSRRCGIKGDDELQ........YRQMTAYL...IQEMGQRLQVSQLCINTAIVYMHRFYA.FH.SFTHF......HRNSMASASLFLAAKV.......................EEQ...PRKLEHVIRAANKCL......PPTTEQNYAELAQELVFNENVLLQTLGFDVA
CCT12_ARATH/28-169                   IIPWFFSREEIERNSPSRRDGIDLKTETR........LRDSYCTF...LEILGERLKVPQVTIATAIFFCHRFFL.RQ.SHAKN......DRQTIATVCMLLAGKV.......................EET...PVTLEDVIIASYERIHKKDLAGAQRKEVYDQQKELVLIGEELVLSTLNFDLC
Q9VE72_DROME/6-144                   DVMSMQQHVELNKAQTMKPIDYRKMNKPG...........VVPMY...IFECAAKLKMKPLTAACAAIVFHRFFR....EVKASD....YDEFLIAAGSLYLAGKI.......................KEDE..SVKIRDVINVAYCTLNRGNDPVDLNDEYWSM.RDAIVQAELLITRTLCFDLN
PCL1_YEAST/19-152                    DIIKFLTDTTL..RVVPSSNYPTPPGSPG...EKHLTRLPSLMTF...ITRLVRYTNVYTPTLLTAACYLNKLKR....ILPRDATGLPSTIHRIFLACLILSAKF.......................HNDS..SPLNKHWARYT..............DG..LFTLEDINLMERQLLQLLNWDLR
PCL2_YEAST/18-146                    EMVQYLASTTASIIKIKKTNSMIDIALPA..........PPLTKF...INRLIKHSNVQTPTLMATSVYLAKLRS....IIPSNVYGIETTRHRIFLGCLILAAKT.......................LNDS..SPLNKHWAEYT..............DG..LLILREVNTIERELLEYFDWDVT
PCL9_YEAST/19-146                    EMIQFLATSTASIIKIRENNNPIQGCRP...........PDLSIF...IKNVVIQSNVQTPTLMATSVYLNKLKS....VIPKNVYGINTTRHRIFLGCLILAAKT.......................LNDS..SPWNKHWTTYT..............EG..LLRIREVNTIERELLEYLNWDVR
CCU41_ARATH/23-148                   RVAESNDLTRRVATQSQRVSVFHGLSRPT..........ITIQSY...LERIFKYANCSPSCFVVAYVYLDRFTH.RQPSLPINS....FNVHRLLITSVMVAAKF................................LDDLYYNNAYY.......AKVG....GISTKEMNFLELDFLFGLGFELN
Q9VKF0_DROME/205-327                 DIFD............EKLHPLTHDQVPDNYDTHNPEHRQ.IYKF...VRTLFNAAQLTAECAIITLVYLERLLTYAELDVGPC......NWKRMVLGAILLASKV................................WDDQAVWNVDYC......QILK....DITVEDMNELERQFLELLQFNIN
CCD11_ARATH/50-182                   DSIACFIEDER..HFVPGHDYLSRFQTRS...LDA.SAREDSVAW...ILKVQAYYNFQPLTAYLAVNYMDRFLY.AR.RLPETS...GWPMQLLAVACLSLAAKM.......................EEIL..VPSLFDFQVA...............GVKYLFEAKTIKRMELLVLSVLDWRLR
CCD21_ARATH/65-197                   DRIKEMLVREI..EFCPGTDYVKRLLSGD...LDL.SVRNQALDW...ILKVCAHYHFGHLCICLSMNYLDRFLT.SY.ELPKDK...DWAAQLLAVSCLSLASKM.......................EETD..VPHIVDLQVE...............DPKFVFEAKTIKRMELLVVTTLNWRLQ
CCD41_ARATH/45-178                   EIIMEMVEKEK..QHLPSDDYIKRLRSGD...LDLNVGRRDALNW...IWKACEVHQFGPLCFCLAMNYLDRFLS.VH.DLPSGK...GWILQLLAVACLSLAAKI.......................EETE..VPMLIDLQVG...............DPQFVFEAKSVQRMELLVLNKLKWRLR
Q9SMD4_SOLLC/51-182                  EELTSLFSKET..EYEISYNVLEK....N...QSFISSRRESVEW...ILKTTAYYSFSAQTGFLAVNYFDRFLL..F.SFNQSLNHKPWMNQLVAVTCLSLAAKV.......................EETD..VPLLLDLQVE...............ESGFLFESKTIQRMEMLILSTLKWKMN
Q9S7H9_SOLLC/61-190                  DELATLLSKEN..EFHLGFQSLIS....D...GSLMGARKEALDW...MLRVIAYYGFTATTAVLAVNYFDRFVS.GW.CFQKDK...PWMSQLAAVACLSIAAKV.......................EETQ..VPLLLDLQVA...............DSRFVFEAKTIQRMELLVLSTLKWKMN
CCD33_ARATH/59-186                   DELSTLISKQE........PCLYDEILDD...EFLVLCREKALDW...IFKVKSHYGFNSLTALLAVNYFDRFIT.SR.KFQTDK...PWMSQLTALACLSLAAKV.......................EEIR..VPFLLDFQVE...............EARYVFEAKTIQRMELLVLSTLDWRMH
CCD61_ARATH/26-154                   TLPHSLFLVEF..QHMPSSHYFHSLKSSA...FLL.SNRNQAISS...ITQYSRKFD.DPSLTYLAVNYLDRFLS.SE.DMPQSK...PWILKLISLSCVSLSAKM.......................RKPD...MSVSDLPVE...............GE..FFDAQMIERMENVILGALKWRMR
CCNE_DROME/330-459                   DVWRLMCHRDEQDSRLRSISML..EQHPG...LQP.RMRAILLDW...LIEVCEVYKLHRETFYLAVDYLDRYLHVAH.KVQKT......HLQLIGITCLFVAAKV.......................EEIY..PPKIGEFAYVT..............DG..ACTERDILNHEKILLQALDWDIS
CCNE2_MOUSE/112-239                  EVWQNMLQKEN..RYVHDKHFQ..VLHSD...LEP.QMRSILLDW...LLEVCEVYTLHRETFYLAQDFFDRFMLTQK.DVNKN......MLQLIGITSLFIASKL.......................EEIY..APKLQEFAYVT..............DG..ACSEVDILKMELNILKALKWELC
CCNE1_CHICK/112-239                  DVWKNMINKEE..TYVRDKLYM..QRHPL...LQP.KMRTILLDW...LMEVCEVYKLYRETFYLAQDFFDRFMATQQ.NVVKT......LLQLIGISSLFIAAKL.......................EEIY..PPKLHQFAYVT..............DG..ACTEDEILSMELIIMKALNWNLN
CCNE1_MOUSE/113-240                  EVWRIMLNKEK..TYLRDEHFL..QRHPL...LQA.RMRAVLLDW...LMEVCEVYKLHRETFYLAQDFFDRYMASQH.NIIKT......LLQLIGISALFIASKL.......................EEIY..PPKLHQFAYVT..............DG..ACSGDEILTMELMMMKALKWRLS
A0A0R4IZF8_DANRE/117-244             EVWNNLLGKDK..LYLRDTRVM..ERHPN...LQP.KMRAILLDW...LMEVCEVYKLHRETFYLGQDYFDRFMATQE.NVLKT......TLQLIGISCLFIAAKM.......................EEIY..PPKVHQFAYVT..............DG..ACTEDDILSMEIIIMKELNWSLS
F6QUN0_XENTR/114-241                 DVWRNMLNKDR..TYLRDKNFF..QKHPQ...LQP.NMRAILLDW...LMEVCEVYKLHRETFYLGQDFFDRFMATQK.NVIKS......RLQLIGITSLFIAAKL.......................EEIY..PPKLHQFAFIT..............DG..ACTEDEITSMELIIMKDLDWCLS
W4XEA0_STRPU/126-253                 EVWTIMTRKEA..LCPRKHDCL..KSHPS...LGE.RMRAILLDW...LIEVCEVYRLHRESFYLAADFVDRYLAAKE.NVPKT......KLQLIGITSLFVAAKL.......................EEIY..PPKLHEFAYVT..............DG..ACTDDQILDQELIMLMTLNWDLT
CCNE_CAEEL/232-360                   KVWSLMVKRDE..IPRATRFLL..GNHPD...MDD.EKRRILIDW...MMEVCESEKLHRETFHLAVDYVDRYLESSNVECSTD......NFQLVGTAALFIAAKY.......................EEIY..PPKCIDFAHLT..............DS..AFTCDNIRTMEVLIVKYIGWSLG
#=GC SS_cons                         HHHHHHHHHHC..HTS-STTCT.TTCTSS...S-H.HHHHHHHHH...HHHHHHHTT--TTHHHHHHHHHHHHHH.HS.---CC......CHHHHHHHHHHHHHHH.......................HSSS..---HHHHHHHT..............TT..SS-HHHHHHHHHHHHHHTTT---
#=GC seq_cons                        -IapahpptEt..phhsp.sYh..ppps-...ls..pMRsILlDW...Ll-VppcacLhtETLaLulshlDRFLu.tp.sls+s......cLQLlGlsulhlAuKa.......................EElh..sPplp-hshlo..............Ds..saopcpllpMEphlLpsLpasls
//
